The Faculty, commonly known as Chiromo Campus, is located on more than 70 acres of land along Riverside Drive off Chiromo Road, 2 kilometres west of the Main Campus. It offers a diverse range of academic programmes in several academic units namely; Chemistry, Biology, Computer Science, Mathematics, Physics, Earth and Climate Science and Biochemistry. The School of Physical Sciences comprises the Departments of Chemistry, Geology, Meteorology and Physics.

Chiromo Library is the Faculty of Science and Technology library.  It is about 2 KM from the Nairobi Central Business District off Riverside Drive and near the old Chiromo Mortuary. It has a sitting capacity of 700 and 12 Study carrels for graduate students and researchers.  It stocks approximately 100,000 hard copy books and bound journals. In addition, it has access to over 70,000 e-books and 50,000 e-journals.

The Faculty of Science & Technology is a leading institution in teaching & research in science, technology and innovations. It was established as a college in 1983 and remains a leading training and research centre in science, technology and innovations. It is located at Chiromo Campus. The mandate of the CBPS emanates from that of the University of Nairobi. This includes training, research, income generation and consultancy in the areas of Biological and Physical Sciences, Mathematics, Computer Science and Informatics.